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A. gambiae85
D. pseudoobscura96
D. melanogaster97
Current Team
Corrado Caggese
Gaetano Tripoli
Domenica D'Elia
Domenico Catalano
Antonio Turi
Flavio Licciulli
Damiano Porcelli
DAPEG Genetic Unit University
of Bari, Italy

CNR Italy
Institute for Biomedical Technology
Section of Bari

Welcome to MitoDrome

About MitoDrome
What's new?
How to search MitoDrome
How to cite MitoDrome

About MitoDrome

The MitoDrome database has been developed with the aim to annotate the complete set of Drosophila melanogaster nuclear genes encoding for mitochondrial proteins [Nucleic Acids Res. (2003), 31:322-4] in order to contribute to their functional characterization. The data collected in MitoDrome derive from the comparison of Human mitochondrial proteins available in SWISSPROT vs. the Drosophila genome, ESTs and cDNA sequences available in the FlyBase database. According to the results, each Drosophila gene sharing significant homology with a human mitochondrial protein was classified as a putative Drosophila mitochondrial gene and annotated in MitoDrome.

What's new?

Using the same approach MitoDrome has recently performed the annotation, at genomic level, of the complete set of OXPHOS system genes in two more species of diptera, the D. pseudoobscura and A. gambiae [Genome Biol. (2005), 6:R11.]. In particular, 78 putative orthologs of the D. melanogaster OXPHOS system have been annotated in each one of the two diptera investigated. The annotation of these genes has been carried out taking into account conservation in amino-acid sequence, intron-exon structure, intron length, and the presence of duplications in the genome. A total of 47 putative paralogs of these genes in the three species have been identified. All these genes have been compared with each other and with their human counterpart and clustered in families. Additional information provided by MitoDrome includes data on mutant insertion alleles of the OXPHOS genes in D. melanogaster.

How to search MitoDrome

The complete list of D. melanogaster genes can be easily accessed from the "DROME list" button in the main frame on top of the page. The genes are here listed in alphabetical order by encoded products and also classified in a functional hierarchy following the GO rationale.

Information on OXPHOS genes can be browsed:
- by using the link of the "Oxphos System" section in the lateral frame of the MitoDrome home page
- by using the advanced "Search" form accessible through the main frame on the top
- by using the BLAST tool accessible through the main frame on the top

The access to data on OXPHOS gene families and on Drosophila melanogaster P-insertion mutants is provided by links in the lateral frame of the MitoDrome home page.


Comments and suggestions:
Prof.Corrado Caggese (caggese@biologia.uniba.it)

Use this email to ask questions, report problems, or suggest improvements:
Helpdesk (bigstaff@area.ba.cnr.it)

How to cite MitoDrome

Published Research assisted by the MitoDrome should cite:

Domenica D’Elia, Domenico Catalano, Flavio Licciulli, Antonio Turi, Gaetano Tripoli, Damiano Porcelli, Cecilia Saccone and Corrado Caggese The MitoDrome database annotates and compares the OXPHOS nuclear genes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae.
Mitochondrion, In Press, Accepted Manuscript, Available online 21 July 2006, PDF


Tripoli G., D'Elia D., Barsanti P., Caggese C. Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae. Genome Biol. (2005), 6:R11.

Sardiello M., Licciulli F., Catalano D., Attimonelli M., Caggese C. MitoDrome: a database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. Nucleic Acids Res. (2003), 31:322-4


Support for MitoDrome has been provided by “Ministero Università e Ricerca Scientifica”, Italy (PRIN99, Programma Biotecnologie legge 95/95-MURST 5%, Project MURST Cluster C03/2000, CEGBA). Currently it is supported by operating grants from “Ministero dell’Istruzione, dell’Università e della Ricerca” (MIUR), Italy [PNR 2001-2003 (FIRB art.8) D.M. 199, Strategic Program: Post-genome, grant 31-063933 and Project n.2, Cluster C03 L. 488/929].


MitoDrome2 v1.05 - Last update: Jul 26th, 2006
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